Craniofacial development is an intricate process under tight genetic and epigenetic control, which involves cell proliferation, differentiation, and interaction in a spatiotemporal fashion . The gene expression process, governing embryonic development or homeostasis, begins with a complex signaling cascade triggering transcription of mRNA from the genomic blueprint (DNA). The transcribed mRNAs are spliced, processed, and translated to proteins, which executes the cellular function. The epigenetic modifications such as methylation of cytosine residues in the DNA or posttranslational modifications of histones add a layer of complexity to the gene expression process.