In recent year number of studies are published in biomedical journals which are related with animal model. I am looking to trial some Ayurvedic Rasayana formulation in aged one in general or a particular disease. Can any one guide us possible biomarkers in general or a particular disease to assess the clinical efficacy of Rasayana drug in aged one.
May I suggest oxidative stress markers? 8-isoprostanes or protein carbonyls content, for example.
In addition to above. May also look for total anti-oxidant capacity in serum and other biological fluids.
eg. I am trying to do work on Amalaki (E.officinalis), which is well known Vyasthapaka ( i.e. arrest aging) drug in Ayurveda. In Clinical set up on which basis we assess the anti-aging effect of Amalaki. What is the appropriate parameters both subjective & objective to assess the therapeutic response of above trial drug.
Do you know the FRAS system launched by Wismerll Company. Thisy is vey easy system to mesure the balance of oxidant and antioxidant using smoall amount of blood sampl. These balances are most omportant for human health. Informations are follows.
http://www.wismerll.co.jp/
Sir your suggestion is interesting but It is not find-able on web http://www.wismerll.co.jp/ because of language problem. If possible please send it in English language, which is very useful for me.
Thanks
Oxidative stress seems to me a good objective marker, although we know that the relationship between objective molecular markers and real life not always is very meaningful.
Cognition levels decrease with agility.so neuro imaging markers or plasmaprotein markers can be of help.
http://dx.doi.org/10.1016/j.cger.2013.07.006
http://dx.doi.org/10.1007%2Fs11920-013-0360-9
Plasma protein biomarkers of the geriatric syndrome of frailty article in pubmed might be of help
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