All biological products undergo sterility testing to ensure that products such as vaccines and freeze-dried products are safe before human use. The culture media growth, (thioglycollate and tryptone soya broth or Soybean casein digest medium) method is based on the observation of turbidity in liquid culture media due to the growth of bacteria, yeast, and fungi, and can detect extremely small numbers of microorganisms. However, this method takes 14 days to provide results. This two‐week period can be a significant limiting factor in the timely release of biologicals, particular for vaccines and products with short shelf lives. Establishing rapid microbial methods that significantly reduce the time for sterility testing of biologicals is needed for uninterrupted supply of products.
Are there any alternative rapid tests to detect microorganisms in either solid or liquid media without using Instruments?
Has anyone considered that the use of GMO soybean (or other GMO) as medium, could make results not as expected?
Has it been studied both the GMO and non GMO medium in order to investigate differences in cells growing, reproduction, metabolism..., including bateria, fungi or mammals?
would you like to elaborate your answer of using GMO soybean as sterility media.
My concern about GMO is that we may have studied their effects for using in humans.
But: have we checked that all diffferent microbes (yeast, fungis, bacteria) and mammal cells behave exactly the same on a soy medium and in a GMO soy medium?
Unless this have been deeply studied, using GMO medium to study a microbe and get concussions, may be wrong as we ignore the full behave, life cycle, metabolism, etc of that microbe in a GMO medium.
Don´t we?
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