I am working on certain nanoparticles where I need to modify their surface with a polymer by Ligand exhcange approach. I came across many papers describing many different methods but I am really confused which one to pick up and which method can assure that the surface modification has done successfully. For eg. some papers are saying to do ligand exchange by sonication at room temperature while some are explaining by using certain temperatures with magnetic stirring.
Kindly help me in finding the most reliable methods among them.
Thank you :)
If you mean by exchanging one ligand with another one then the thermodynamic stability of the complex matters. If you use sonication you have to develop method, optimize it. If not further sonication May break the complex and ligand would be snatched apart. Same is the case with other methods like heating or magnetic stirring or so. Characterization of the material in the aftermath of ligation is a must so as to confirm it.
Thank you so much Dr.Shrikant and Ashwini , I will definitely follow your comments and work accordingly :)
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