I think Lornoxicam oral tablets contain  "Lactose mono-hydrate" as sweetening agent with the other formulation Inactive ingredients

u can use taste masking agents or sweetening agents to mask the taste

Taste is a crucial factor that determines the palatability of oral dosage form and patient compliance. It also gives a unique identity to a product and thereby provides a competitive advantage to a company, especially in the case of over-the-counter products. There are several taste masking techniques available, which either involve modification of bitter active pharmaceutical ingredient itself or the formulation. This article reviews the concept of perception of taste, various taste masking techniques available, selection of appropriate taste masking technique, and evaluation tests for taste masking.

Taste masking techniques

An appropriate taste masking technique can affect both product quality and process effectiveness. Following are various taste masking techniques that can be used to taste mask bitter Active Pharmaceutical Ingredient (API):

1.Sweetener, flavorant, and other excipient addition. This is one of the simplest techniques used in taste masking. Excipients such as sweeteners and flavorants can be added to taste mask bitter API. Sweeteners, being highly water soluble, dissolve in saliva and coat the taste buds, thereby retarding the interaction of bitter API with taste buds. Flavorants enhance the formulation and give it a distinct taste. They are to be added in addition to primary taste masking agent. Certain cooling flavorants like menthol numb the taste buds and retard bitter taste perception . Additionally, other excipients such as bitterness inhibitors can also be added.

Complexation. In complexation, the drug molecule fits into the cavity of a complexing agent, i.e., the host molecule, forming a stable complex. Complexation decreases the amount of drug particles, which are exposed to taste buds, thereby reducing the perception of bitter taste .

Coating. Coating is one of the best methods of taste masking. It can involve coating of a tablet containing bitter API or coating of the bitter API particles themselves. Ideally, the polymers selected in coating should be such that they prevent API release in oral cavity and allow its release in the absorption window of the API .

Matrix entrapment. Matrix entrapment involves trapping of drug into bulky matrix and thereby retarding its contact with taste buds. The matrix may contain polymeric, resinous, gelling, or lipoidal materials .

Prodrug formation. Prodrugs are molecules that are initially inactive but, upon biotransformation, are converted to active forms. Prodrug formation leads to physicochemical modification of bitter loci and thereby inhibits/retards their interaction with taste receptors .

Salt formation. Salt formation usually retards the solubility of API in saliva and thereby retards its taste perception .

 Other techniques such as granulating with polymeric material, adding effervescent excipients, and rheological modification of liquid preparations can be used for masking the taste of bitter API .

Recent developments in the field of taste masking. Stimuli responsive drug delivery systems incorporating pH sensitive, ion sensitive polymers have been developed for masking bitter API taste . Lycopodium-derived microcapsules have been used to taste mask ibuprofen . Techniques like nano hydridizing and wet spherical agglomeration have also been used for taste masking .

Dear All,

Thanks a lots for giving me information

Hi Rites,

I think that a godd way can be to load your oral strip with drug formulated in a nanostructured system (lipidi or polymeric nanoparticles, etc...). In this way you can to mask the taste and improve the pharmacokineticks.

Best wishes

Polymer coating for taste masking can not be used in buccal or sublingual delivery applications. Once the drug is released in oral cavity, the bitterness will be there. Complexation is more effective in these applications.

Agreed with Y Lan...in this case Complexation will be a better choice. However, addition of flavor and sweetners can also help to mask the bitter taste.

Agreed with Shuaib Khan.  Since most of NSAIDs have a throat burning sensation after you swallow  them, additional flavor will definitely help. Bitterness in such drugs  is not so bad, the biggest issue is burning feeling. Try to use complexation  to reduce the burning first, and then add some flavors.

Thanks a lots to all

Try to use VEEGUM, i m sure u will get tremendous results.

Thanks a lots Kuldeepji for giving me information. Is Veegum  used as a taste masking of lornoxicam?

Ya sure. try to make wet granulation with veggum.

Vegum will work here as a adsorbent.

Adsorption of bitter tasting drug can be considered as the less saliva soluble versions of these

drugs. Adsorption involves preparing a solution of the drug and mixing it with an insoluble

powder that will adsorb the drug, removing the solvent, is dried and used in the preparation of

the final dosage form. Many substrates like veegum, bentonite, silica gel and silicates can be

used for the preparation of adsorbate of bitter drugs(

Dear Kuldeepji,

Thanks a lots for giving answer. 

Actually we are making oral film strip. I will try with this veegum.

Try coating the oral film in LACTOSE you will definatly see improvement in the intensity  of the bitter taste of the API.

Thanks a lots