Can anyone suggest how to do sub-lingual MICE immunization?

06 June 2013 1 10K Report

Looking for help in doing sub-lingual vaccine delivery in mice. Thanks.

We have done some preliminary studies in sublingual vaccine delivery with some antigens. Delivering the drops sublingually is a bit tricky. It is necessary to anaesthetize the animals to ensure that they do not swallow the administered dose immediately. Also, there are some reports where administration of drugs like pilocarpine to prevent the swallowing reflex for some time. Attached a publicn from our group.

Mala D.Menon

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