Reference links are welcome
https://ispenordic.nemtilmeld.dk/images/descriptions/13540/20_april/02_Defining_Limits_and_Doing_MACO_Calculations__by_Pierre_Devaux.pdf
You can refer above document for calculation of PDE.
FOR NOEL you need to refer published articles and need to find the most relevant one to select POD.
Apart from it, our team, including toxicologists, provides PDE certification services to pharmaceuticals companies.
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