Right, thanks but actually I need a numerical value to use in my model which is about transport of aspirin through polymeric matrix. Drug is a kind of reservoir in the core.
Thank you for the answers, the diffusivity for aspirin-PVA system is 0.29x10^(-9) and Paclitaxel (Taxol)-PLA system 6.29x10^(-12) cm^2 x s^(-1), these are the closest results that i was able to find from the literature data. But the range is broad. Paclitaxel has a 7-8 times bigger moleculer weight compared to aspirin and represents a different dissolution character. Also PVA is a small molecule compared to PLA. So it is really hard to guess it. The best is to measure it as you said, but unfortunately it seems unlikely just now.
It is not hard to measure it with molecular dynamics but i should syntheses drug-polymer particle as well. For now i will look at effect of changing diffusion coefficient and use the range from the literature in my model. Thanks again for the helps!
Can anyone help with the diffusion coefficient of Paclitaxel (PTX) in PLGA polymer (polylactic-co-glycolic acid)?
Actually, it is very hard to give a standard answer to this question. However, you can use some experimentally measured values to guess it in a range. For example, you can definitely say, it will be smaller than the diffusion coefficient of water or gases in PLGA (you can find the related data about that); so that your range for diffusivity would be limited. After all, you can claim that it can take any value within the specified range.
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