Can anyone help with method of determining the Bioavailability of Amphotericin B in blood or methods to quantify Amphotericin B in serum?

Ibeh Raymond Chigozie @Ibeh-Raymond-Chigozie

19 November 2017 1 321 Report

Am working on ways of reducing the toxicity of Amphotericin B without affecting the bioavailability.

Hello Obed!

May be these works could help you:

Determination of amphotericin B in human plasma using solid-phase extraction and high-performance liquid chromatography.

Eldem T, et al. J Pharm Biomed Anal. 2001.

Determination of amphotericin B, liposomal amphotericin B, and amphotericin B colloidal dispersion in plasma by high-performance liquid chromatography.

Egger P, et al. J Chromatogr B Biomed Sci Appl. 2001.High-performance liquid chromatographic determination of amphotericin B in a liposomal pharmaceutical product and validation of the assay.Eldem T, et al. J Chromatogr Sci. 2000.High-performance liquid chromatographic determination of amphotericin B in plasma and tissue. Application to pharmacokinetic and tissue distribution studies in rats.Echevarría I, et al. J Chromatogr A. 1998.Determination of amphotericin B in human serum by liquid chromatography.Lopez-Galera R, et al. J Chromatogr B Biomed Appl. 1995.High-performance liquid chromatography of HIV protease inhibitors in human biological matrices.

Review article

Aarnoutse RE, et al. J Chromatogr B Biomed Sci Appl. 2001.

Regards

Liliana

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