I need papers about the effect of the acute effect of metformin in rodents as well as the chronic effect. I need to know which doses they use and which rout.
Oral administration of metformin is the most common, probably because that is how it is delivered clinically.
I did my M.S. thesis on the acute effects of metformin. Here's a link to the full-text:
https://www.researchgate.net/publication/46276246_A_single_dose_of_metformin_improves_whole_body_insulin_sensitivity_and_alters_cellular_redox_state_in_skeletal_muscle_of_Zucker_fafa_rats
Article A single dose of metformin improves whole body insulin sensi...
Please apply to the papers of Prof V.Anisimov from our Institute and to my own review
Metformin in obesity, cancer and aging: addressing controversies Aging (Albany, NY), 2012 Vol.4(5)320-329
- Metformin reduces vascular production of vasoconstrictor prostanoids in fructose-overloaded rats.
Puyó, AM, Borroni, JS, Boudou S, Santander Y, Carranza A, Donoso AS, Peredo HA. Autonomic and Autacoid Pharmacology. 2012 Apr; 32(1Pt 2): 9-14. doi: 10.1111/j.1474-8673.2012.00469.x. Epub 2012 Feb 29.
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