Can anyone help calculate the area under the plasma drug concentration-time curve (AUC)?

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Muhammad Naeem

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Robert D Arnold

You can calculate using excel or just paper and a calculator. See http://www.boomer.org/c/p4/c02/c0208.html or http://www.statisticshowto.com/how-to-find-the-area-under-a-curve-in-microsoft-excel/ for simple explanation. Depending on how sharp rise/fall you may need to calculate using log-trap method. Good luck

Rakesh Kumar Tekade

Either you can use softwares associated with that instrument like chemstation as well as some stated above by Dr. Arnold. Other alternate can be manual method, which may be tricky.

In this method, you can cut the chromatogram into as much as accurate shapes like rectangles and triangles. Then you can determine the area of these shapes by simple calculation. At the end you can sum up all areas to get area under curve.

Best wishes Muhammad

Rakesh

Muhammad, Please do so only if you do not have automated software mean, I am so sorry I do not use these softwares. But you may try to download some trial versions.

Regards

Neelesh Mehra

Dear

You may calculated the pharmacokinetic parameter of obtained plasma-drug concentration time data either manual or using of software Kinetica..

Thank you all for your comments. @ Neelash Mehra...I downloaded trail version of Kinetica..I need only Cmax, Tmax and AUC. Do u have link for kinetica tutorial or updated version download link, please.

D'Souza Joseph

You can use "R" programming with the "PRACMA" package. R is an open source softwares, you can use it for free. With the "PRACMA" you can find the area under the curve with trapezoidal rule with a single simple command..