What is an ideal biological sample to check the effect of a research drug on a neurotransmitter?

Hi, I am going to investigate on my research drug regarding influence on neurotransmitter. Kindly give your valuable suggestions regarding ideal biological sample like brain homogenate or serum or...

07 August 2014 9,484 7 View

How can we estimate the level of various monoamine neurotransmitters in a biological sample?

06 July 2014 9,491 29 View

How can we decide the dose of a herbal drug for its therapeutic effects?

Please give me some ideas about dose fixation for an extract for its therapeutic effect.

02 March 2014 5,234 13 View

Can someone suggest a software based application regarding blood pressure and cardiotonic activity?

I want some software based application, which would be really helpful to explain to my student.

11 December 2013 6,920 9 View

Does anyone have detailed information regarding reputed online certificate course for clinical research?

I want to know any information regarding online courses related to clinical pharmacy.

11 December 2013 4,225 8 View

Can someone advise on the doping drugs?

Please prove information with reason.

08 September 2013 1,751 3 View

Does anybody have methods for in-vitro estimation of hypoglycemic agents?

It is urgent. I have a project on diabetes. Due to the unavailability of animals I want to perform experiments in-vitro.

07 August 2013 5,599 4 View

Which health services are provided by pharmacists in different countries?

As all of us know, pharmacists play an important role in heath services. Your valuable suggestions regarding different services provided by pharmacists in healthcare in different countries like...

07 August 2013 2,195 3 View

Can anyone suggest the methods to find the effect of l-thyronine on respiration rate?

Please help me if you have a simple procedure to find the effect of l-thyronine on respiration rate in rat.

07 August 2013 6,127 1 View

Can anyone give information on biogenetic drugs working on endocrine disorders?

Biotechnological drug

07 August 2013 9,470 2 View

I am interested in medicinal chemistry field, which books are highly recommended to learn from?

I am at the beginner level in drug design and drug discovery, and I am interested to learn more about this field. Which books are highly recommended to start from and gives me all essential...

02 March 2021 8,437 2 View

How could I process data in RCT to include it in meta-analysis?

I'm in the process of doing a meta-analysis and have encountered some problems with the RCT data. One of my outcom is muscle strength. In one study, I have three different measurements of muscle...

25 February 2021 7,603 3 View

How to empty large intestine in mice ?

Hi all I am working on colon-targeted drug delivery for which I kept mice fasting for 6h using fasting grills during scotophase (dark period). I observed liquid fecal content in the cecum and...

23 February 2021 7,701 2 View

Can I use a protein-devoid condition as my negative control in ELISA?

Hello, I am running a sandwich-type ELISA where I am trying to inhibit a protein-protein interaction using small molecules. For each experiment, I determine my Z' (Z-prime) to determine the...

23 February 2021 7,429 1 View

How does the injection volume impact LLOQ and ULOQ in regression analysis (LC-MSMS)?

Hello, I have run into an issue that has sparkled a debate at work: is the LLOQ/ULOQ impacted by injection volume under the following circumstances: 1) Same dilution factor of all samples 2)...

23 February 2021 9,159 3 View

Can two EC50 values with different hill slopes be compared?

Hello, I fit a classical dose response curve Y=Bottom + (Top-Bottom)/(1+10^((LogEC-X)*HillSlope)) to my data (not related to inhibitors etc). The model I use is purely qualitative but it fits...

23 February 2021 8,155 5 View

ANCOVA controlling baseline in RCT - how to perform power analysis and sample size estimation?

Hi, I have a simple question. I am hoping to perform a power analysis/sample size estimation for an RCT. We will be controlling for baseline symptoms, and using post-treatment or change scores as...

19 February 2021 2,648 23 View

Which alginate is best for making gel for wound dressing application?

We are looking into utilizing alginate as a gel coating on an HDPE substrate for drug delivery. I would like to ask the community about their experience with alginate and which commercial sources...

15 February 2021 4,319 4 View

Any natural extract (that is easily available) or any drug combination triple which i can use against gram negative?

I'm working on gram negative i want to use any natural extract (plant extract) or triple drug combination against its biofilm formation.

14 February 2021 1,403 3 View

Should the AUC in a concentration-time graph of a subcutaneous implant be roughly the same for poeple?

I have 2 concentration time curves of a subcut drug implant. the first group has a peak around the 50 day mark where as the second group does not. Both groups received the same implant by the same...

10 February 2021 2,305 3 View