The systemic antioxidant therapy is one of the therapeutic options for oral mucosal lesions. In Localized delivery of antioxidant molecules to the oral mucosal lesion, will the oral mucosal cells uptake/absorb the antioxidant molecules? Will the antioxidant molecules perform their action when delivered locally? Which route of delivery (systemic/local) of antioxidant molecules can have better activity?
Yes you can coat or surface with an emulsion like anti-oxidant material to deliver drug to oral lesions. All fat soluble vitamins, syrups of plant origin stay on the surface of mucosa and absorb directly after other antioxidants also either from the diet or from any other source.
It would be a major advantage to deliver antioxidant molecules locally at the desired site. Developing such formulations is critical, but possible. Major step is to select suitable stabilizing agents to protect the antioxidants from degradation or adopt some coating/encapsulation/tagging with polymeers.
Anti oxidants can be applied topically.,Many anti oxidants are vitamins which can be absorbed thru mucosa.Most effective is vitamin C
Topical application of precursor and analogues of vitamin A is found to be effectice in the treatment of few potentially malignant disorders however prolonged use Of vitamin A has many adverse effect on the body.
Another antioxidant than the aforementioned, melatonin, also crosses barriers quite good.
In the sense of application for the local wound, the formulation could be easily developed but whether the specific moity is effective could only be varified by research. Anti oxidants is wide basket of drugs / herbs.
yes, anti oxidants can be applied topically as well as systemic. The articles and files i am attaching for your reference
Can be give both topically and systemically also
Literature also supports in both the ways
Topical antioxidants beyond doubt serve as the best choice in treatment of oral mucosal lesions especially in potentially malignant disorders. Clinical trials using topical retinoids ,lycopene etc., are reported but still exclusive topical antioxidants for oral use with standardisation of dosage and direction of usage yet to be achieved
Yes.Anti oxidants are very helpful.Most common anti oxidants like vitamin C is well absorbed also through oral mucosa and sub lingually ,since it is water soluble vitamin.
Antioxidants can be used topically on oral mucosal tissues, as many antioxidant agents are composed of some materials that aid in upcoming of the components by oral mucosal parts. For example, Aloe vera is an active antioxidant in which Lignin is used to be absorbed into deeper tissues of oral mucosa.
In addition, to prevent chemotherapy induced oral mucositis from taking place, topical use of some agents are studied. My last research wss about topical application of olive oil in order to prevent chemotherapy induced oral mucositis. Antioxidant proerties was one of the most important justifications of olive oil effectiveness as it was effective in prevention.
https://authors.elsevier.com/a/1a8H53GZbnmkp-
This is the url of that article
- Badges
- Science topic
- Similar topics
- Biological Science
- Botany
- Pharmaceutical Botany
- Plant Extracts