If yes, please provide the dosage and please refer your answers to reliable references if possible.
I have not used Ketamine+ medetimine anesthesia for longer duration of action. I am using zoletil and rumpun mixture for the anesthetic purpose (it sustain for 3 hr) in case of mice. You can try using this.
Ketamine is a dissociative anesthesia, u will not get effective anesthetic effect for longer duration.
For long duration surgeries (over 1 hour) we always use general anesthesia (isoflurane) plus a preoperative analgesic such as buprenorphine.
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