Can a compound have LogP value around 0.05 and LogD value around 4.02?

06 January 2021 0 7K Report

I understand that there might be huge differences between LogD and LogP for ionizable compounds. Normally, logD should be lower than logP for ionizable compounds.

But can LogD value be significantly higher than LogP, say in my case LogP = 0.05 and LogD = 4.02. I am using ocatnol/DPBS pH7.4 for determining LogD and ocatnol/MilliQ for determining LogP. Please comment.

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