Can a cohort study design be used to compare the effect of two treatment regimens over a period of time like - the resolution of symptoms, improvement in the Quality of Life, the occurrence of ADR during follow up.
Neither of the treatments compared are new interventions.
Can prospective cohort study be an alternative to RCT as the aim is not to test a new therapy (intervention).
A randomised controlled trial is still the design of choice to compare treatments/ interventions, whether or not the treatments are 'new' interventions. If there are already patients receiving the different treatments, then an observational study such as a cohort study could be used to compare outcomes in the two groups. However this would really be an initial exploratory study, any definitive results would require a design that controls for confounding.
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