Hi everybody !
I am looking for the best animal model "to copy" the human eye. In fact I'm working on a project where I need an eye model with similar structure to mime the intravitreal injection in human. Consequently the thickness, resistance, anatomy, etc should be as similar as possible. We have started in a mouse model, but we need to pursue on a bigger eye. Do you have any idea (and references) about a validated model to help me ? Thanks a lot in advance.
Best regards.
Hi, Daniel
Have you checked this book?
Animal models in eye research. Panagiotis A. Tsonis. Elsevier. 2008.
(You must check especially Table 13-1.)
https://www.nyu.edu/projects/desplan/PDF/2009%20Sprecher%20whole%20book%20on%20eye.pdf
Also, you can check these articles
Rabbit as an animal model for intravitreal pharmacokinetics: Clinical predictability and quality of the published data. Eva M. del Amoa, Arto Urtti.
Intravitreous Injection for Establishing Ocular Diseases Model. Kin Chiu, Raymond Chuen-Chung Chang, and Kwok-Fai So.
Intravitreal injection of fibroblasts: the pathological effects on the ocular tissues of the rabbit following an intravitreal injection of autologous skin fibroblasts. CATHRYN A HITCHINS AND IAN GRIERSON
https://www.researchgate.net/publication/5398559_Animal_Models_of_Dry_Eye
Best wishes
Article Animal Models of Dry Eye
Hi Sedat,
In first, thank you very much for your help.
I didn't see this book. It looks very interesting, especially the part on rabbit. I'll transfer that to my colleagues too.
About the articles, my initial list includes only the first one (very interesting by the way). I'll have a look on the other ones.
Many thanks and have a nice week-end.
Daniel.
Daniel, if you are looking at pharmacokinetics after an intravitreal injection the rabbit eye should work. If you need similar anatomy then you have to move to monkeys (ultimate model but expensive and not easy to obtain) or pig (similar size and vasculature, does,t have a macula but has a visual streak area similar to our macula)
- Badges
- Science topic
- Similar topics
- Biological Science
- Anatomy