Now a days different auto ESR methods and machine are being used in different countries. International Society of hematology might certify these methods before their marketing. Recently I followed a case (age 74 yrs, male) of febrile illness for the last 1 month with consolidation right lung, not responding different antibiotics. His ESR was done by an auto ESR analyzer on 20th Nov, 2023 was 14mm and on 30th Nov, 2023 , was only 02 mm. I repeat the case with standard Westergren Method and found to be 60mm on 01st December 2023. How this can be explained?