Dysbiosis of microbiome and probiotic treatment in a genetic model of autism spectrum disorders. - PubMed - NCBI
Preprint Dysbiosis of microbiome and probiotic treatment in a genetic...
Treatment of Shank3 KO mice with L. reuteri induced an attenuation of unsocial behavior specifically in male Shank3 mice, and a decrease in repetitive behaviors in both male and female Shank3 KO mice. In addition, L. reuteri treatment affected GABA receptor gene expression and protein levels in multiple brain regions. This study identifies bacterial species that are sensitive to an autism-related mutation, and further suggests a therapeutic potential for probiotic treatment.