Are your compounds inhibiting TNF-alpha production from immune cells or inhibiting TNF-alpha activity by binding?

Nagendra sastry Yarla @Nagendra-Sastry-Yarla

26 December 2013 1 8K Report

Is TNF-alpha your target site? TNF-alpha is not an enzyme or receptor. You claim that your compounds were docked on TNF-alpha.

Data Natural Product Research, 2013-Supp Info

José Luis Andreu

Etanercept binds to TNF and inhibits its biological action. Anti-TNF monoclonal antibodies do the same but also can destroy cells expresing TNF on their membranes.

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