Are there any suggestions for removing a CBz group from an amine in the presence of a thioether and an ester?

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Maddali V S Murali Krishna

N-Cbz-protected amino acids reacted with various aryl amines in the presence of methanesulfonyl chloride and N-methylimidazole in dichloromethane to give the corresponding arylamides in high yields without racemization under these mild conditions.

Ref: Organic Chemistry Portal; Protected Amino-Groups in Multi-step Syntheses

L. Mao, Z. Wang, Y. Li, X. Han, W. Zhou, Synlett, 2011, 129-133.

Chinpiao Chen

Please try the mixyure of Pd/C and Pd(OH)2/C. Ref. Chem. Pharm. Bull. 57(12) 1421—1424 (2009)