Dear Dr. Gerry/Gerre A Quinn

There is a claim that COVID-19 mRNA vaccine could impair the innate immunity by suppressing the type I interferon responses leading to increased risk to infectious diseases and cancer. Also, vaccine could alter the production of inflammatory cytokines by innate immune cells following stimulation with SARS-CoV-2 stimuli.

Studies report that in combination with strong adaptive immune responses, the reprogramming of innate responses could either contribute to a more balanced inflammatory reaction to SARS-CoV-2 infection or a weakened innate immune response.

These are claims, and strong claims would require strong evidence. You may want to refer to the article attached below for more information.

Article Letter to Editor “Innate immune suppression by SARS-CoV-2 mR...

Regards,

Malcolm Nobre

Lipid nanoparticles (LNP) which bring the mRNA to cells are masked against immune cells using poly-ethylene glycol 2000 (PEG2000) attached to a lipid (pegylated lipid). The PEG2000 needs to be shed before being taken up by a cell to deliver the mRNA. The rate at which the PEG2000 is shed gives the LNP its stealth ability against immune cells. The adverse effect of PEG2000 is the development of an anaphylactic reaction against this molecule. Anaphylactic reactions against any types of vaccine is common and usually happens in the minutes after vaccine administration. We usually stay 15 to 30 at the administration center to monitor and safely address this adverse effect.

The adverse effects reported in the previous answer seem to refer to a retracted paper.

Thanks Louis.

I had not considered this aspect when I first asked the question.

Gerry

Also thanks Dr Malcolm Nobre, I have heard about the downregulation of Interferon but I thought it might be confined to the duration of the vaccination process.

I was actually thinking that even minor covid infections of OC43 or HK1 train the innate immunity to respond quicker to challenge, so avoiding this step migt interfere with the training of the immune response, especially in children.