Hi

Beside vitamin E I would also suggest vitamin D as it has been shown in several reports that it has potent anti-inflammatory properties. However, you need to check the plasma level first to adjust the dose and duration of supplementation. If the levels are normal you can supply up to 600 IU/day for adults and 400 IU/day for children. If there is insufficiency or deficiency you can go to up to 4000 IU/day for adults and 2000 IU/day for children.

Wishes,

Bassem

thanks for your reply

but the efficacy of vitamin E and D is in decreasing inflamation but not in decreasing  inflamatory mediators in sepsis 

Hello,

Some vitamin such as A, D and B9 have an important potential on Treg (pic1).And,

some micronutrients such as zinc has similar effect about controlling of  NFkappaB (pic2).

Doxycline downregulates inflammatory cytokines. you can google more information about this sublect. There is quite a bit of information and publications about Doxy and cytokines, Hope this was helpful  Terry M Fredeking profile on researchgate.com has more study's on this subject. Thanks Terry M Fredeking

http://www.hindawi.com/journals/jir/2011/370872/

As you know there has been a plethora of attempts to ameliorate the inflammatory syndrome. There was a very interesting article on the effect of alfa3 integrine blockade in Blood recently.

Ioannis Mitroulis and Triantafyllos Chavakis. a3b1 is INTEGRAL to septic neutrophils. Blood 2014 124(24) 3507

Unfortunately from the clinical perspective so far there is no  effective methods to decrease inflammatory mediators during the sepsis

Activated C Protein is extremely promising but I guess is still under experimental trial

Modulation of Cytokine and Cytokine Receptor/Antagonist by Treatment with Doxycycline and Tetracycline in Patients with Dengue Fever.

This publication and other inflammatory cytokine study's are available by clicking on my name above. It may be helpful with your sepsis question.

There are some researches about CVVH and elemination of inflamatory mediator