Hi Kelly,

..... good question ... and probably you do not find any database as long as the definition of the supplement will cover "physiological effects".

Definition of food supplement by EC:

"‘food supplements’ means foodstuffs the purpose of which is to supplement the normal diet and which are concentrated sources of nutrients or other substances with a nutritional or physiological effect,"

"The labelling, presentation and advertising must not attribute to food supplements the property of preventing, treating or curing a human disease, or refer to such properties."

DIRECTIVE 2002/46/EC OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL

https://eur-lex.europa.eu/legal-content/EN/TXT/PDF/?uri=CELEX:32002L0046&from=EN

As long as we do not talk about pharmacological effects after supplement we cant talk about pharmacodynamic interactions between drugs and supplements (if you think about pharmacological interactions in your question ...). In another word, drugs do not interact with physiology sensu stricto.

Moreover "indications" in case of supplement always and still are around

"...a nutritional or physiological effect," so as long as we talk about physiology we cant talk about any contraindications.

Of course in whole this context I'm not talking about situations in which we take for example milk and tetracyclines orally at the same time etc. Its simply food interactions and not must be "artificially" assigned to supplements.

Best regards,

Tomasz

Thank you, yes you are correct.

Hi Kelly Gardiner

I've always used Micromedex and InterCheckWeb as databases for the identification of potential drug-drug interactions, but information on drug-herb interactions has often been lacking or missing.

A free on-line tool that you could consult is the one implemented by Memorial Sloan Kettering Cancer Center, which you can find at the "About Herbs, Botanicals and other Products" section at the following link:

https://www.mskcc.org/cancer-care/diagnosis-treatment/symptom-management/integrative-medicine/herbs/search

Here you can find an accurate description of adverse reactions and herb-drug interactions, with related literature references.

Hoping to help you,

Kind regards

Riccardo and I run into the same problem. The current data bases lack most supplements. Someone must have a system somewhere that has this information including ayreuvedic, homeopathic, herbs, etc.

You can try interaction checker in either ( medscape.com or drug .com

I asked the question again in case a new database is available. FYI. When I order atypical antipsychotics, I tell my patients that the medication I am ordering will not increase weight, cholesterol or blood sugar. Sadly, they read the package insert and it says it increases all 3. However, certain atypical do not yet, the FDA puts a generic warning in the package insert for all of these medications!!!