Hi, there is one trial that tried methylphenidate in Parkinson's disease patients with gait freezing.

http://www.sciencedirect.com/science/article/pii/S1474442212701060

Thanks Daniel, I'll look this up.

overall, I have not found them helpful, usually because they are too powerful and too stimulating. The more advanced the condition, the more it seems that way, in addtition to a worsening risk of a psychosis-inducing effect. IF I was left with no other options, I would titrate up starting with minuscule doses. Prior to this, need to give full trials of MAO-B inhibitors, DA agonists, CDP-choline as an adjunct, COMT inhibitors. Hope this helps

Hi, one negative study in PD http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068005/, a case for side effects http://www.ncbi.nlm.nih.gov/pmc/articles/PMC315486/, and a trial for ADHD and tics http://clinicaltrials.gov/ct2/show/NCT00441649. I didn`t find anything particularly for MovDis in children

Thanks Boris, I have not seen much either from my limited search of the MPH literature. I'm more familiar with animal studies using this compound but none have assessed fine motor movements in MPH treated animals.

I think it depends on the movemet disorder that's causing the problem. Someone mentioned Parkinson's disease above; since PD is caused, or at least accompanied by death of many dopaminergic neurons, I don't think that methylphenidate or other monoamine releasers such as amphetamine would be helpful for the condition. There isn't enough dopamine present to be "released" by the drug if you will. Maybe in other types/causes of striatal dysfunction these drugs could produce a different result.

Hi, Stephane, They`ve tried small doses of amphetamines to treat for PD. Even the old MAO- B inhibitor selegiline metabolises to amphetamines. Concerning animals, I`ve found 2 more interesting (for me) abstracts: http://www.ncbi.nlm.nih.gov/pubmed/6420823

http://www.ncbi.nlm.nih.gov/pubmed/15582106