Glucosinolates; plant secondary metabolites are known to be very effective against cancer, but some reports suggest that they are also toxic if used as primary food source. Does any researcher has any published material on toxicity limits of these compounds?
Hi, Saeed,
Ref.: Das, S., Srinibas, Tyagi, A. K., and Kaur, H. (2000). Cancer modulation by glucosinolates: A review. Curr. Sci. 79: 1665–1671.
According to Das S et al and Lavecchia T et al, overdose of glucosinolates can cause thyroid dysfunction causing hypertrophy and goiter.
glucosinolates in turnip, cabbage, brocolli, toxic in hyperthyrodism (High in T3, T4) (goiter disease) also anything over dose first stage cause allergen
As per the saying every thing is bad in excess, same is applyied to glucosinolates. Glucosinolates have been proved to have antitumer and anticancer properties but on the other hand they cause goitre if consumed in quite excess. In a normal person they dont cause any harm if consumed normally.
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