Dear researchers,
Anticancer peptides(ACPs) with cell-penetrating properties can enter to cytoplasmic space of cancer cells and induce cell death. but, I could not find the database that specifically contains anticancer peptides with cell-penetrating properties. in databases such as CancerPPD, only anticancer peptides, without mention of the anticancer mechanism or cell-penetrating properties, have been collected.
How can I collect big data of cell-penetrating anticancer peptides?
(I have found a few cell-penetrating anticancer peptides such as p28 or buforin 2b from different papers. but it is so small data.)
Thank you so much
Farid
Dear Farid Nasiri ,
You might have look at:
Gautam, Ankur, Harinder Singh, Atul Tyagi, Kumardeep Chaudhary, Rahul Kumar, Pallavi Kapoor, and G. P. S. Raghava. "CPPsite: a curated database of cell penetrating peptides." Database 2012 (2012).
Unfortunately, today I was unable to reach the server, but this might be temporarily. The same is true for:
Tyagi, Atul, Abhishek Tuknait, Priya Anand, Sudheer Gupta, Minakshi Sharma, Deepika Mathur, Anshika Joshi, Sandeep Singh, Ankur Gautam, and Gajendra PS Raghava. "CancerPPD: a database of anticancer peptides and proteins." Nucleic acids research 43, no. D1 (2015): D837-D843.
An excellent review (and overview of available databases and servers) can be found here:
Article Empirical comparison and analysis of web-based cell-penetrat...
Hope this helps you a bit further.
Best regards.
Dear Farid Nasiri,
I recommend you to search for it here: https://datasetsearch.research.google.com/
Dear Rob Keller,
Thank you so much for your precious and significant answer. However, I search for the ACPs that have inherent properties to penetrate cancer cells without the need for conjugation with a CPP. but databases such as "CancerPPD " and "CPPsite " don't mention other activities of collected peptides. therefore I could not find cell-penetrating anticancer peptides in these databases.
Kind regards
Nasiri
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