I want to synthesize Ibuprofen , want to know lab synthesis protocol or scheme
Hello For your information, Ibuprofen is very cheap to buy:
http://www.sigmaaldrich.com/catalog/search?term=15687-27-1&interface=CAS%20No.&N=0&mode=match%20partialmax&lang=en®ion=AU&focus=product
In Regards of a potential synthesis, Have a look at Org and Biomol Chem, 2014, 12(48) p9760, might be a good starting point. Good Luck
Synthesis
Two synthetic routes to ibuprofen:-
(This image was copied from www.chem.vt.edu without permission)
There have been many commercial and laboratory publications for the synthesis of Ibuprofen. Two of the most popular ways to obtain Ibuprofen are the Boot process and the Hoechst process. The Boot process is an older commercial process developed by the Boot Pure Drug Company, and the Hoechst process is a newer process developed by the Hoechst Company. Most of these routes to Ibuprofen begin with isobutylbenzene and use Friedel-Crafts acylation. The Boot process requires six steps, while the Hoechst process, with the assistance of catalysts, is completed in only three steps.
Cheminor Drugs have developed a process for an improved version of ibuprofen based on chiral synthesis. The move is significant given that pure S-Ibuprofen (the active form of ibuprofen) could near halve the regular ibuprofen dosage, besides improving the side-effect profile.
However the human body can convert the inactive (R) form into the (S) form, so eventually 100% of the ibuprofen taken becomes active. The process discovered by Cheminor is therefore unlikely to have commercial significance.
http://www.rsc.org/learn-chemistry/resources/chemistry-in-your-cupboard/nurofen/5
http://www.chm.bris.ac.uk/motm/ibuprofen/synthesis.htm
http://pubs.acs.org/doi/abs/10.1021/ed100892p?journalCode=jceda8
dear Sunil,
The Ibuprofen was derived from propanoic acid by the research of Boots company in 1960s. The Boots synthesis was based on 6 steps, started with the Friedel-Crafts acylation of isobutylbenzene and ended with hydrolysing the nitrile to the desired product of Ibuprofen. While, the Hoechst Celanese managed to develop a newer process with the same technique but with catalysts was completed in only 3 steps. For further details about each processes please visit www.ch.ic.ac.uk / Ibuprofen – a case study in green chemistry .
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