Any one aware of any polymorphism or genetic variation associated with the pharmacology of frusemide?

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Tomasz Grabowski

See an example below:

Article A Pharmacogenetic Investigation of Intravenous Furosemide in...

Best regards

Tomasz

Karel Allegaert

as additional reflection (it is not fully clear if you look at PK, PD or safety), but PK: glucuronidation ? safety: synergism on ototoxicity ? does this help ?

Usman Mohammed

@karel

I wish to know if there's any genetic polymorphism/variation in the pharmacology of frusemide. Whether at the level of safety, pk or pd?

Is there anything of concern in this regard sir?