we are trying for methylation of hydroquinone. Please suggest any method for that.
domethane (4.98 ml, 9.99 mmol) was added dropwise to a solution of hydroquinone (4.00 g, 36.33 mmol) and KOH (8.32 g, 148.30 mmol) in 75 ml of DMSO. The reaction mixture became dark and was stirred at r.t. for 1 h at 25°C. The reaction mixture was neutralized by adding an aqueous saturated solution OfNH4Cl. The product was extracted with dichloromethane (3 x 50 mL). The organic phases were washed several times with water (5 x 150 mL) to eliminate DMSO, then dried over anhydrous Na2SO4. The solvent was evaporated at reduced pressure. A white solid was isolated (4.87 g, yield 97percent).
Dear Avtar,
You can use the hydroquinon in strong acidic medium with R-OH where R indicate any Alkyl group in your case its methyl,
Another way by using methyl iodide but it leads dimethylated multiple products.
Hope you will get some idea about your synthesis
Read British paper 1575,237
Best regards
Muhammad imran khattak
Hi,
Please see the following paper in which an O-alkylation reaction of hydroquinone with excess methanol was carried out by using alkaline metal ion-exchanged zeolite catalysts at various phases of methanol in a slurry type reactor.
Korean J. Chem. Eng., 26(3), 649-653 (2009).
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