To my Knewlodge it's a NO, but there is a ligand-ligand similarity for virtual screening of unkown target structures. There is also a ligand-ligand interaction where scientists studying metal complexes are always studying to to see their biological effect

https://www.researchgate.net/post/Can_we_do_ligand_ligand_docking

Here's a tool for studying drug-drug interactions:

https://chemicalx.readthedocs.io