I am looking for differences between euchromatin and heterochromatin in terms of either functional, biochemical or biophysical. The experiments must be novel and unpublished. This is for my assignment purpose. Hope everyone can help me with this. Thanks a lot
Hello Boo,
I'm not sure I understood your question well.
There are many techniques that allow you to observe this profile. One of the ways you find these regions is through marks associated with histones. You can perform experiments with antibodies to each type of profile by Chip-seq for example.
Let me know if this is the type of help you are looking for or something more specific.
Best regards,
Ronaldo
Hello, I do not understand your question. Do you look for methods of study for differential expression of heterochromatin and euchromatin? Or is your goal to find a new method for this? Thanks
Apologies for the confusion. Let me rephrase my question.
Researchers use the terms “open” and “closed” to describe chromatin that is either permissive or repressive to transcription. Most people call these forms of chromatin euchromatin and heterochromatin. While older studies have focused on in vitro characterization of the sedimentation properties and the structure of reconstituted
chromatin arrays, few in vivo studies have been done with the same amount of detail.
Write a one-page proposal to study the differences (biophysical, biochemical, and/or functional) between euchromatin and heterochromatin in tissue culture cells. Rules:
1) This study may not be one discussed in class, in your readings, or published already.
2) Define how heterochromatin and euchromatin differ in the context of your study.
3) State clearly what exactly you will measure.
4) State the hypothesis that will be tested.
5) State how our current understanding of euchromatin and heterochromatin will
change if you detect/do-no-detect a difference.***
*** Yes, this study allows for negative results.
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