I studied synuclein, amyloid, Tau interactions using TEM. I know it is difficult to understand multiple protein or peptide interactions. I want to use bioinformatics to map the complexity of protein interactions in brain cell during degeneration.
Prof Rao,
String is a good data base.
http://string-db.org/newstring_cgi/show_input_page.pl
I think this database probably has all the questions that you are looking for. I use it to increase my knowledge on Alz.
Regards
Ashish
I think any Protein interaction tools like string,bind etc. are able to answer your query.you can try to find which type of interaction persist between APP and tau protein which are responsible for alzheimer type of neurodegenarartive dementia.
Dear Sir,
I know that dynamics of interaction ca be studied by wet lab technologies and it will be making your results more clear and accurate, which will confirm the process simulation and modelling studies. I think, wet lab technique first applied and then developed simulation will result a better understanding. Complementary to each other. saving time and making reproducible results.
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