Any data, findings against this circuit idea ?

I have idea that ketamine and serotonergic agents activate via 5-HT 2A (or other serotonergic receptors) on IPN which activates the IPN output,that activates the MRN which inhibits the theta states (via SUM, MS/DBB, ..) and promotes SWA in cortex by activating claustrum, and enables slow wave oscillations in hippocampus by direct projections.

through this pathway induce ketamine and serotonin anesthesia, SWS and unconscious state normally linked to hippocampo-cortical replay of memories.

Please update me what doesn't work.

  • DOI:10.13140/RG.2.2.29677.97766
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