There are four known genes encoded by HB genome called C, P, S, and X. Some studies developed detection assay targeting the conserve region of the S gene, and some targeted conserve regions of both the S & C gene. Again, I found a commercial kit targeting the X gene's conserve region.
Which factors should be taken into consideration during targeting genes for HBV detection assay development?
Jack Bee Chook
These are the three most conserved regions in HBV genome. S region offers additional advantage as gene deletion is least reported in this region.
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Sohail Hussain
The S gene codes for the surface antigen (HBsAg), which contains the a determinant, the main region for induction of a protective humoral immune response. So S is most important in detection and resistance.
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