I recently read an article named [Oral delivery of lycopene-loaded microemulsion for brain-targeting: preparation, characterization, pharmacokinetic evaluation and tissue distribution]. The microemulsion in this article is made through a similar and common manufacturing method as SMEDDS. First find out the composition of oil, surfactant and co-surfactant, and then mix it with a small amount of water. It enters the gastrointestinal tract for oral absorption, which is consistent with SMEDDS. It looks very similar to the self-emulsification reaction. So can the dosage form in the article be regarded as the delivery method of SMEDDS targeting to brain?