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Questions related from Yongze Chen
The phenomenon of various amino acids (AA) adsorption onto the silica surface is widely studied. Many people simply add silica into a solution of AA, stir it, centrifuge it, and wash the solid...
03 April 2025 1,645 4 View
Recently I have been trying to understand the effect of silica gel pore size on a mechanochemical reaction. It involves intense milling of spherical silica gel of similar particle size...
18 February 2025 9,105 3 View
I am doing a mechanochemical synthesis and trying to find the induction time of the reaction. Thus, I take samples every 30 seconds and inject each sample into the HPLC to detect the time required...
18 February 2025 5,540 4 View
I am trying to analyze short peptides containing hydrophobic aromatic amino acids. The samples are insoluble in water or any organic solvent but only soluble in a very acidic solution such as...
11 December 2024 1,464 5 View
I have trouble interpreting the DSC/TGA diagram. I have 2 samples (an amino acid and a dipeptide). Both of them were heated from 30 to 360C at 4K/min with nitrogen as a purge gas. For the...
04 December 2024 7,072 3 View
I used a mobile phase (50 mM potassium phosphate monobasic + 8 mM sodium hexanesulfonate adjusted to pH 2.5 by phosphoric acid) to analyze my samples on a Luna Omega Polar C18 column. How can I...
27 November 2024 3,639 3 View
I run mechanochemical reactions that involves the use of a large amount of catalyst (1:1 molar ratio to the reactant). When I try to understand the effect of amount of catalyst on the reaction, I...
24 July 2024 10,396 1 View
Here is one case: I want to perform X + Y in the presence of Z catalyst in a 50 mL milling jar with 8 12 mm milling balls and investigate whether the the amount of catalyst affect the yield of the...
19 June 2024 3,177 1 View
After condensation of amino acids (they do not contain any protection groups), I believe that I have produced leucine peptides such as di-leucine, tri-leucine, leucine diketopiperazine,...
17 June 2024 2,136 1 View
Whenever I mill silica gel with other materials in stainless steel milling jar, the color of the powder goes from white (initial) to dark and darker color like yellow, dark yellow, brown, dark...
17 June 2024 4,066 3 View
My amino acid condensation reaction (the reagents do not have protection groups) utilizes K2CO3 as a base. K2CO3, the resulting peptide product and unreacted amino acids all have decent solubility...
17 June 2024 8,173 3 View
I milled TiO2 in a stainless milling jar for a prolonged period (10 hours) and immediately noticed that some TiO2 were deposited onto the jar surface and could not be washed and brushed away. It...
12 September 2023 8,337 3 View
