Tony Tiller

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Questions related from Tony Tiller

How to avoid blockages of centrifuge filters when filtering polydisperse liposome samples for separation of free hydrophobic drug?

I'm using ultrafiltration for the separation of free curcumin from liposomes. The tubes are 1ml 0.45um cellulose acetate filter tubes (Corning Spin-X) and the centrifuge I'm using is the Thermo...

02 September 2020 9,128 2 View

What benchtop high pressure homogeniser for downsizing liposomes would you choose and why ?

Emphasis on: Minimising drug and lipid loss Minimising number of passes Achieving unimodal distribution Maintaining high encapsulation efficiencies Ease of use and maintenance

25 November 2019 2,144 2 View

Is it scientifically appropriate to dose-normalise non-linear compound kinetics?

If comparing formulations of curcumin reported in the literature, which are also available commercially, by their Cmax values, if they have all used different doses, is it scientifically...

11 December 2018 4,818 5 View

What scanning electron microscopes would be recommended for determining liposome characteristics and why?

Looking for some cost effective recommendations for a SEM on a budget for determining large unilamellar liposome characteristics (approx 200nm) ie size and particle uniformity, distribution etc....

26 November 2018 2,256 7 View

Would you normalise data in a bio-availability study, how would you do it and why?

It's a comparison of liposomal vitamin C to non-liposomal vitamin C. There were 21 geometric mean data points taken from each test group. I have the SD for each data point, there is some...

13 November 2018 7,879 3 View