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Questions related from Syed S. Hasnain
Although the donut concept of the optic disc is widely published in glaucoma but it is not supported by any histology in the textbooks.
03 December 2023 1,732 2 View
The nasal nerve fibers (NFs) enter the nasal part of the disc. NFs originating from the nasal macular area proceed directly to the temporal part of the ONH whereas the NFs originating from...
06 October 2018 4,808 2 View
Glaucomatous field defects corroborate with the arrangement of nerve fibers in the retina or of the prelaminar region of the ONH. Superior and inferior arcuate NFs originate at the temporal...
29 August 2018 5,642 3 View
Optic neuropathy is a broad umbrella term which includes optic atrophies due to various causes in which NFs are being atrophied or shrinking in size, but not totally vanishing. Glaucoma is also...
30 June 2018 2,533 5 View
It is widely mentioned that due to elevated IOP, the Lamina Cribrosa starts bowing posteriorly, which in turn distorts the laminar beams and starts pinching the axons and thus triggers the...
26 June 2018 8,272 9 View
The most puzzling question in glaucoma which is rarely discussed: one million or so densely packed nerve fibers (NFs) in the ONH are being destroyed in an orderly sequence from peripheral to...
21 June 2018 4,390 5 View
NFs in glaucoma are always being destroyed in an orderly sequence from peripheral to central and never haphazardly. For the orderly loss: NFs should be lying loose as they are in the prelaminar...
05 May 2018 8,430 15 View
I hypothesize that due to inherent temporal tilt of the disc the temporal nerve fibers are severed earlier therefore the central vessels are shifted nasally. Analogy: if the roots of a tree were...
07 June 2014 959 5 View
It is mentioned that larger Vertical CDR a risk factor for glaucoma. It is puzzling: why would a larger vertical CDR be a risk factor and not the larger horizontal CDR? Can it be possible that...
14 May 2014 8,695 9 View
Excavation which is also described as cupping is the characteristic feature of the glaucomatous disc. Non-glaucomatous optic atrophies are flat (non-excavated). Histology of the end-stage...
03 April 2014 3,642 2 View
I hypothesize that due to sinking of the Lamina Cribrosa, the capillaries and smaller vasculature are stretched and broken at the scleral edge, a fate similar to being met by the nerve fibers....
02 April 2014 5,962 5 View
It is widely mentioned that the nerve fibers are present in the rim area only whereas the physio/pathological cups are devoid of nerves. If true, then we should be expecting the corresponding area...
15 December 2013 5,607 6 View
It is widely mentioned that physiological cup starts enlarging in glaucoma due to raised IOP. What are the physiological cups? According to Wolf’s Anatomy the physiological cups are produced due...
27 November 2013 2,743 1 View
Reversal of cupping has been reported in cases of glaucoma in which IOP has been surgically reduced. If reversal was truly occurring then we should have also witnessed the regaining of nerve...
13 November 2013 577 6 View
What is the explanation of the superior and inferior notches occurring in glaucomatous disc whereas we observe no such notches in other kind of optic disc diseases? Thanks
07 September 2013 5,859 7 View
It is widely mentioned that the end-stage glaucomatous disc (ESGD) is 100 % cupped. Textbooks describe the histology of the ESGD resembling a bean-pot, which appears much larger than the size of...
07 September 2013 8,412 2 View
The term cupping implies that the physiological cups start enlarging concentrically due to raised IOP so turning them into pathological cups in glaucoma. Term cupping was originally given by...
07 July 2013 9,363 3 View
It is widely published that nerve fibers are present in the rim area only whereas the central cupped area of the disc is empty. In other words the optic disc is analogous to a doughnut. It also...
02 July 2013 6,798 0 View
Histology of the end-stage glaucomatous disc reveals an empty crater- no nerve fibers at all. Where did the nerve fibers go? In contrast the histology of the non-glaucomatous disc such as due to...
27 June 2013 3,875 10 View
wouldn't it be a good that anyone can express his/her ideas about a disease without the fear of rejection? Peer reviews are never rejected if we attach some big name to it even though the articles...
01 January 1970 6,089 5 View
