Pedro J Romero

6 Questions 24 Answers 0 Followers

Questions related from Pedro J Romero

How safe is using RBCs derived from inmortalised cells for blood transfusion?

I wonder about the risks of using an immortalised adult erythroid line (BEL-A) as a source of functional RBCs for human transfusion. Even if RBCs are “terminal cells” there may be some risks of...

25 October 2018 8,711 3 View

Has chlorpromazine been tried as palliative in SCD?

Chlorpromazine (CPZ) is an antipsychotic drug of widespread use. Early studies have shown that human erythrocytes (RBC) become cup-shaped in the presence of CPZ, due to its asymmetric...

17 May 2016 3,893 3 View

Does autologous IgG attenuate complement activity of normal plasma?

Paradoxically, high doses of Immunoglobulin G from pooled human sera have been used intravenously for treatment of some chronic inflammatory diseases (Newburger JW et al. N Engl J Med 3 15:341,...

25 August 2015 2,921 5 View

Does clotrimazole extend the lifespan of normal human RBCs?

The gardos channel appears partly involved in the selective trapping and destruction of senescent human red cells. As clotrimazole is a well known blocker of this channel, an effect of CLT on...

10 February 2015 2,237 16 View

Does clotrimazole bind to haemoglobin? Is binding dependent on iron redox state?

It is well known the high affinity of clotrimazole for the haeme moiety. I wander whether its binding to haemoglobin has been studied and if it depends on the oxido-reduction state of the Fe...

16 January 2015 8,399 2 View

Is canola oil really dangerous for human consumption?

I have come across on very contradictory claims about the danger canola oil may have on human health. Does somebody know well-founded scientific work on this subject favouring either view? I...

01 January 1970 3,837 10 View