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Questions related from Pedro J Romero
I wonder about the risks of using an immortalised adult erythroid line (BEL-A) as a source of functional RBCs for human transfusion. Even if RBCs are “terminal cells” there may be some risks of...
25 October 2018 8,701 3 View
Chlorpromazine (CPZ) is an antipsychotic drug of widespread use. Early studies have shown that human erythrocytes (RBC) become cup-shaped in the presence of CPZ, due to its asymmetric...
17 May 2016 3,883 3 View
Paradoxically, high doses of Immunoglobulin G from pooled human sera have been used intravenously for treatment of some chronic inflammatory diseases (Newburger JW et al. N Engl J Med 3 15:341,...
25 August 2015 2,912 5 View
The gardos channel appears partly involved in the selective trapping and destruction of senescent human red cells. As clotrimazole is a well known blocker of this channel, an effect of CLT on...
10 February 2015 2,230 16 View
It is well known the high affinity of clotrimazole for the haeme moiety. I wander whether its binding to haemoglobin has been studied and if it depends on the oxido-reduction state of the Fe...
16 January 2015 8,389 2 View
I have come across on very contradictory claims about the danger canola oil may have on human health. Does somebody know well-founded scientific work on this subject favouring either view? I...
01 January 1970 3,832 10 View