Konstantin Byrgazov

3 Questions 13 Answers 0 Followers

Questions related from Konstantin Byrgazov

Synergy scores: HSA and Bliss positive, but Loewe is negative. How to intepret?

Hi everyone! Recently I was doing a lot screening of drug pairs in 5 osteosarcoma cell lines using this amazing website https://synergyfinder.fimm.fi. I am puzzled why a lot of combinations have...

09 May 2018 9,204 3 View

Any recommendations on the software for structure-based drug design?

I have the protein structure and would like to design the small molecule compounds to interfere with the protein function. I know which pocket to target. Last time I was in medicinal chemistry was...

19 May 2016 7,898 6 View

Can anyone help with 5' RACE from the cDNA?

I seek for your advice on the strategy on 5' RACE if I have a sample with cDNA of the patient. As I understood from the literature search, I should start with the 5' priming of the cDNA. In this...

19 February 2014 1,699 5 View