Eleni Kourtidou

7 Questions 9 Answers 0 Followers

Questions related from Eleni Kourtidou

What demethylating reagent do you suggest?

I would like to demethylate a substrate which carries one aryl methoxy group and heterocycle moieties. I tried some methods by using HBr and BBr3 but they didn't give any demethylated product. My...

04 August 2016 5,017 19 View

MSD Check Tune failed. Does anybody have an idea about the reason?

I work on an Agilent LC/MS system with the Agilent 6120B Single Quadrupole mass detector in ESI positive mode. I have tuned the instrument (in Autotune mode) with Agilent ESI Tuning Mix. However,...

05 February 2016 9,498 5 View

Why do I get a relatively tall peak at 3.82ppm for H-NMR and missing a primary amine's peak?

H-NMR spectrum of my compound is very clear. All peaks present on spectrum (and their integrals) are as expected, except: 1) A peak corresponds to protons from a primary amine is missing. I...

24 September 2015 3,513 12 View

How can I prevent reactant degradation?

I'am trying a N-arylation with K2CO3 in DMSO. It seems to produce the desired product but one of my reactants seems to degrade. I have too many byproducts on my reaction mixture. Any idea to...

17 October 2014 667 5 View

Can anyone help with purifying product from reaction mixture with column chromatography?

After discovering a solvent system (EtOH:CH2Cl2 1:15) with TLC silica plates, I run my reaction mixture with C.C. in order to purify my product. I packed a relatively high and wide column with...

04 August 2014 5,608 4 View

Can I use boron tribromide for the demethylation of a methoxy group on a compound which carries also a primary arylamine?

Do I have to protect the amine?

29 July 2014 3,952 3 View

Discrepancy between TLC and LC-MS?

LC-MS analysis gives one peak and the molecular weight of this peak corresponds to my desire product. However, my sample gives three spots on TLC with EtOH:CH2Cl2 1:3. Do you have an explanation...

12 June 2014 8,185 3 View