Dominique Blanchard

5 Questions 10 Answers 0 Followers

Questions related from Dominique Blanchard

Antibody : loss of binding at high concentration (beyond saturation) Why?

Hi everyone, It is commonly observed that some antibodies presents a binding saturation curve that goes down at high concentration (at concentration beyond saturation). Does anybody have a good...

21 August 2020 965 5 View

What are the options for protein sequestration in the cytoplasm or for inducing degradation?

Hi, I'm looking for mutation (fusion with signal peptide) to sequester a protein within the cytoplasm or to induce it's degradation. I was thinking to something like CAAX, KDEL, or other motif....

25 August 2017 2,418 3 View

Where do you see interest of GMP synthetic peptides?

Bioactive peptides such as antimicrobial, antitumor, immunizing peptides are bioproduced. I would like to know what are the limitation for producing them through peptide synthesis and what are...

14 March 2017 5,835 0 View

Do you know of a multispecies olfactory receptor library?

I'm actively looking for a library of olfactory receptor. The goal is to have the broadest diversity. Do you have any idea about academic or commercial resources? Any advice for generating such...

30 June 2015 8,605 3 View

CGMP compliant protein affinity TAG

Hello, In order to speed up our protein production process, we would like to use an affinity purification TAG. Some well-known TAGs work very well (strepTag) but identifying a cGMP compliant...

01 January 1970 1,221 3 View