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Questions related from Dina Morshedi
As we know so far, around 25 proteins and peptides are known to involve in amyloid disease. If we assume that the fibrillation is an intrinsic feature of all polypeptides, and that we have tens...
01 January 2019 3,216 3 View
In an assay if we find that the best pH for a protein which will be injected to the patients, is around 3, it is ok that during formulation, we use an acidic buffer.In similar situation if we...
05 May 2018 2,713 2 View
I want to have a cell line with high content of a-synuclein. I have looked at many reports which in them two different systems were used to over-express of a-synuclein. Does any one know which...
07 July 2015 3,353 6 View
Is it Ok to Analysis of the significantly / meaningfully of an inhibitory effect with anova-test or t-student?We work on a compound which can decrease the cytotoxicity effect of another compound...
12 December 2014 9,837 3 View
We are working with a protein to induce fibrillation forms. Our FTIR (deep peak at 1624 qnd 1695) results and AFM images (twisted long fiberils) confirmed fibril formation. In spite of these...
09 September 2014 2,623 10 View
When I look at the SDS-page pattern of alpha synuclein in some studies its band appears higher (around 17 KD) than the real place of its molecular weight (14.4 KD). However, our purified protein...
07 July 2014 9,195 3 View
Why does the presence of different contamination change the pH of media in different ways?
05 May 2014 3,162 1 View
In many proteins such as lysozyme and alpha-synuclein, only a limited part of protein participate in cross-beta sheet and fibril formation. In alpha synuclein from 140 residues only about 60...
02 February 2014 1,410 0 View
