Dina Morshedi

4 Questions 7 Answers 0 Followers

Questions related from Dina Morshedi

Why the sizes of nanoliposome decrease after drug entrapment?

Using DLS, we found that the average size of our fabricated nanoliposome decreased from 180 to 140 nm, however we did not find any reason for it. The drug was a monoclonal antibody.

16 January 2023 6,740 3 View

Which system is better for overexpresion of alpha-synuclein in a dopaminergic cell line such as SH-SY5Y : adenoviral vector or lentiviral vector?

I want to have a cell line with high content of a-synuclein. I have looked at many reports which in them two different systems were used to over-express of a-synuclein. Does any one know which...

18 July 2015 885 5 View

Why does deamidation have a very important role on the protein stability?

In preformulation process , assessing deamidation should be done in short term. In deamdation reactions ( we have fiffernt reactions), Asn usually is the main residue to be converted. Does Asn...

24 April 2015 1,469 3 View

Why are FTIR and AFM results inconsistent with Far-UV CD ones for the fibril form of a protein?

We are working with a protein to induce fibrillation forms. Our FTIR (deep peak at 1624 qnd 1695) results and AFM images (twisted long fiberils) confirmed fibril formation. In spite of these...

17 September 2014 3,811 9 View