Besma Benredjem

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Questions related from Besma Benredjem

Do drugs that are injected i.t in rats reach the supraspinal system and how long does it take to clear them from spinal cord?

I am injecting intrathecally (between L5-L6) , in rats, cannabinoid analgesics and I was wondering if they can reach the brain and have effects there as well ? Also I need to pretreat with...

08 January 2021 5,708 4 View

Can you inject a drug dissolved in 100% ethanol or DMF intrathecal in rats ?

I need to perform antagonism experiments and I inject intrathecally the antagonist 30 minutes prior to the drug treatment. One of my antagonist is soluble in DMF or DMSO (DMF in my case) but very...

06 July 2020 1,677 1 View

How much ethanol and DMSO/DMF are tolerable for intrathecal injections in rats ?

I need to inject drugs that are very poorly soluble in aqueous solutions. My stocks are in either 100% ethanol or 100% DMF or DMSO. When I dilute them in saline, the solution is not clear. What...

06 July 2020 4,879 0 View