Andre Bonavita

9 Questions 16 Answers 0 Followers

Questions related from Andre Bonavita

Does anyone have a reference for incidence of CIPN associated with vincristine?

I know that chemotherapy induced peripheral neuropathy (CIPN) is a common with vincristine treatment. However I didn't find any good reference showing the incidence of this side effect in...

15 April 2020 2,920 0 View

Did some experience problems using female Swiss mice in comportamental studies?

For 4 years I've been using Swiss female mice in a model of drug-induced neuropathic pain. I commonly see a latency time of 8-10 seconds to thermal stimuli in control groups and about 4 seconds...

20 September 2019 1,032 0 View

Why ketamine/xylazine in mice is not working?

In my postdoc I always used the anesthesic protocol of ketamine(80mg/kg)/xylazine (10mg/kg) injecting 0,1ml ip for balb-c mice. And it works very well. However now using Swiss mice from another...

15 April 2019 771 5 View

Why my animals are not getting diabetics in a streptozotocin-indeced model?

We are trying induced diabetes in Wistar rats using Streptozotocin. But none till now are diabetic. Protocol used12h fasting60mg/kg of Streptozotocin in 0.1 M citrate buffer, pH 4.5 (ip)prepared...

10 May 2016 5,923 11 View

Subacute APAP-induced liver failure model?

Hi, I'm working with acute liver failure for 7 years, but now I'm interested in a model of subacute liver failure in mice induced by acetaminophen. However I didn't found any paper in PubMed. Does...

03 May 2016 2,708 3 View

What is the best treatment schedule to treat chronic pain?

I'm looking for the best treatment schedule to treat my animals with chronic pain. In literature I saw basicaly to schedules: the first one made 5-7 consecutive days (once a day) and evaluate the...

30 April 2015 2,524 7 View

Does anyone knows a method for liver mast cell isolation?

or a method to evaluate mast cell activation in liver tissue?

12 September 2014 8,208 3 View

What is the best dose for BBG intraperitoneal injection treatment?

I want to block P2X7 receptors in rat using BBG (brilliant blue G). Does anybody know what the best dose for this treatment (by IP injection) is?

09 June 2014 6,566 2 View

How does formalin directly activate nociceptors?

During the formalin pain test, how does formalin induces the neurogenic phase one response? Does it directly open sodium channels or does it act by means of a receptor or any other mechanism?

09 June 2014 9,924 3 View