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Hypoxia SHOULD decrease the generation of reactive oxygen species(ROS) due to limiting oxygen levels. However, it has been reported that the levels of intracellular ROS paradoxically increase...
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We all know that under stress (nutrient starvation) condition, AMPK is activated which functions as a sensor of cellular energy. Does this increase/ activation of AMPK in different starvation...
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We know that ROS stabilizes HIF-1a during hypoxic condition. But the point is how much ROS (conc.) is required for HIF-1a stabilization? Please refer me the related articles. Many thanks!
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