7 Questions 15 Answers 0 Followers
Questions related from Alex Avdeef
I would have thought that the solubility of glycine hydrochloride (not that of the zwitterion, nor that of the zwitterion adjusted to low pH with HCl!) would have been measured and published long...
23 September 2023 6,077 0 View
Several reports/patents/papers state that the pKas of POSACONAZOLE are 3.6 (piperazines) and 4.6 (triazoles), but I can't track down WHO measured these values. Based on reliable solubility-pH...
18 July 2023 3,540 0 View
In the course of preparing a journal/book publication based on my original research, I prepare a set of drawings using commercial software designed for scientific applications. Am I the copyright...
09 June 2023 7,034 0 View
Most drugs are ionizable in aqueous solutions: their solubility is pH-dependent. Ideally, prediction of solubility of new drug entities involves training sets consisting of INTRINSIC solubility,...
18 November 2020 2,843 2 View
M6G and M3G are "chemical chameleons", which can adopt their conformations according to the polarity of the medium in which they find themselves in (e.g., 'folded' or 'extended' conformations)....
16 January 2020 7,018 0 View
Yalkowsky's GSE is popular and elegant. However, it does not work very well for all solid quaternary ammonium drugs and many zwitterionic drugs. It's thermodynamic basis assumes a CONSTANT...
11 April 2019 310 5 View
Dear Colleagues, I am starting to write a book, "Intrinsic Solubility Data for Pharmaceutical Research." I have studied 1325 publications and have compiled 6352 entries of intrinsic solubility....
22 February 2019 4,638 6 View
