Alex Avdeef

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Questions related from Alex Avdeef

POSACONAZOLE - what are its accurate pKa values?

Several reports/patents/papers state that the pKas of POSACONAZOLE are 3.6 (piperazines) and 4.6 (triazoles), but I can't track down WHO measured these values. Based on reliable solubility-pH...

18 July 2023 3,529 0 View

Under which circumstances can drug SALT solubility in water be converted into drug INTRINSIC solubility?

Most drugs are ionizable in aqueous solutions: their solubility is pH-dependent. Ideally, prediction of solubility of new drug entities involves training sets consisting of INTRINSIC solubility,...

18 November 2020 2,813 2 View

In the General Solubility Equation, why is entropy of fusion assumed to be constant?

Yalkowsky's GSE is popular and elegant. However, it does not work very well for all solid quaternary ammonium drugs and many zwitterionic drugs. It's thermodynamic basis assumes a CONSTANT...

11 April 2019 301 5 View

Have you published drug solubility vs pH data in aqueous solution?

Dear Colleagues, I am starting to write a book, "Intrinsic Solubility Data for Pharmaceutical Research." I have studied 1325 publications and have compiled 6352 entries of intrinsic solubility....

22 February 2019 4,631 6 View