In the preparation of glycerol, the intermediate compound 2-chloropropan-1,3-diol is formed after addition of HOCl to allyl alcohol. How?

When HOCl is added to propene, the product is 1-chloro 2-propanol. However, when the same HOCl adds to allyl alcohol, the expected product is 3-chloropropan-1, 2-diol. But actually,...

09 October 2019 8,232 4 View

What are the other solvents suitable for Wohl-Ziegler Reaction (or other free radical reactions) beside toxic CCl4?

02 March 2017 6,967 3 View

How to prepare 2,7-dimethylpyrene? Is it possible to use Friedel-craft alkylation method?

The preparation of 2,7-bis(1,1-dimethylethyl)-pyrene is carried out using tert-butyl chloride in presence of AlCl3. Whether the same protocol can be used to prepare 2,7-dimethylpyrene...

04 May 2016 3,329 6 View

Is there any way to purify 3-bromo-5-TIPS thiophene having minor impurity of 2-bromo-5-TIPS thiophene?

I did the halogen dance reaction of 2-bromo-5-TIPS thiophene using LDA/methanol to get 3-bromo-5-TIPS thiophene. But there reaction was not completed 100% and there is ~5-10% of starting material...

11 December 2015 126 2 View

Can the selective Rosenmund-von Braun Reaction of dibromo-benzothiadiazole be possible?

09 October 2015 3,762 6 View

How does the use of additives (e.g.ionic-liquid based electrolytes) enhance the stability of a dye-sensitized solar cell?

Generally it was found that the use of additives in redox mediator [iodide/triiodide] cause not only improved performance but also increase device stability. In particular, I want to know the...

06 July 2015 4,849 4 View

Which one would be efficient method for N-alkylation of aromatic amides e.g. 1,3-bis(acetamido)benzene?

The base promoted N-alkylation [SN2] using NaOH, KOH, NaH, K2CO3 etc of simple aromatic amines is well reported. Can the alkylation of amides be performed easily, then which method should be...

04 May 2015 9,402 8 View

Is further treatment of BuLi possible on thiophene-substituent without affecting -boronic ester already present on it?

01 February 2015 494 3 View

Which reagent will provide a clean lithiation reaction of 4-(thiophen-2-yl)aniline?

The commonly used lithiating reagent, BuLi can be used for the thiophene-derivatives having primary amine; e.g. 4-(thiophen-2-yl)aniline. Alternatively which reagents can be used to get the...

31 December 2014 5,594 5 View

Which halogenation would be most feasible for the aromatics among -Cl, -Br and -I?

For instance, among N-chlorosuccinimide, N-bromosuccinimide and N-iodosuccinimide, which one would give most feasible respective halogenated product once reacted with an aromatic?

10 November 2014 4,297 5 View

MD MOE RMSD

How to calculate the RMSD values for a MD simulation using MOE?

07 August 2021 0 0 View

MD MOE RMSD

How to calculate the RMSD values for a MD simulation using MOE?

07 August 2021 0 0 View

fatal error

When I tried to energy minimization my system, I got fatal error as below. Fatal error: Atomtype opls_116 not found Although I've already added this line: ; include water #include "oplsaa.ff/spc.itp" to [molecultype] directive in my topology.

16 June 2021 0 0 View

fatal error

When I tried to energy minimization my system, I got fatal error as below. Fatal error: Atomtype opls_116 not found Although I've already added this line: ; include water #include "oplsaa.ff/spc.itp" to [molecultype] directive in my topology.

16 June 2021 0 0 View

fatal error

When I tried to energy minimization my system, I got fatal error as below. Fatal error: Atomtype opls_116 not found Although I've already added this line: ; include water #include "oplsaa.ff/spc.itp" to [molecultype] directive in my topology.

16 June 2021 0 0 View

fatal error

When I tried to energy minimization my system, I got fatal error as below. Fatal error: Atomtype opls_116 not found Although I've already added this line: ; include water #include "oplsaa.ff/spc.itp" to [molecultype] directive in my topology.

16 June 2021 0 0 View

flexibility of polymers chain

effect of double bond on the flexibility of polymers

07 April 2021 0 0 View

Formulation of polymer color flakes

I am writing to request some information for making polymer color flakes. I would appreciate the help.

17 March 2021 0 0 View

Chlorinated organic formation in odor control scrubbers using hypochlorite?

I'm involved in a study of odor control technologies for municipal wastewater treatment plant. One of the control options involves a chemical 2-stage (acid/alkaline) packed bed scrubber. The...

03 March 2021 3,661 2 View

I am interested in medicinal chemistry field, which books are highly recommended to learn from?

I am at the beginner level in drug design and drug discovery, and I am interested to learn more about this field. Which books are highly recommended to start from and gives me all essential...

02 March 2021 8,437 2 View